Former Crystal Palace boss Tony Pulis 1 Crystal Palace boss Tony Pulis has left the club with immediate effect after a disagreement over transfer policy.The Eagles manager reportedely believed he deserved a bigger transfer budget and has been left frustrated at missing out on a series of key targets, including Gylfi Sigurdsson, Michu and Steven Caulker.And that led co-chairman Steve Parish to hold crunch talks with Pulis in a meeting held in London on Thursday evening.Neither party has been able to come to an amicable agreement regarding the future of the club, leading the Palace boss to leave Selhurst Park less than two days before they kick off their Premier League campaign against Arsenal on Saturday evening.Pulis succeeded Ian Holloway at the south London club in November with Palace sat rock bottom of the Premier League and performed miracles to help them stave off relegation and finish 11th in the table.Current assistant manager Keith Millen is expected to lead the side in the opening game of the season against the Gunners, live on talkSPORT.Crystal Palace later confirmed they would hold a press conference at 3pm on Friday.More to follow.
May 10 2018GI Dynamics® Inc. (ASX: GID), a medical device company that is developing EndoBarrier® for patients with type 2 diabetes and obesity, is pleased to announce the meta-analysis, “Effects of the Duodenal-Jejunal Bypass Liner on Glycemic Control in Type 2 Diabetic Patients with Obesity: A Meta-analysis with Secondary Analysis on Weight Loss and Hormonal Changes,” by Pichamol Jirapinyo, MD, of Brigham and Women’s Hospital in Boston, Massachusetts, and Diplomat of the American Board of Obesity Medicine, has been published in Diabetes Care, the journal of the American Diabetes Association.The meta-analysis is comprised of 17 published studies that evaluate EndoBarrier (also referred to as duodenal-jejunal bypass liner [DJBL]) outcomes in patients with type 2 diabetes and obesity. The primary outcomes of the meta-analysis were change in hemoglobin A1c (HbA1c) and homeostatic model assessment of insulin resistance (HOMA-IR). Secondary outcomes were change in weight and change in hormones critical to the regulation of metabolic and bariatric disorders: GIP, GLP-1, PYY and ghrelin.”The analysis shows that DJBL is effective at treating diabetes in this patient population with a reduction in HbA1c of 1.3%, and with many patients coming off diabetic medication,” said Jirapinyo. “This reduction in HbA1c is significantly better by 0.9% as compared to optimal medical management alone. In addition, this study demonstrates that patients who receive DJBL experience significant improvements in insulin resistance and weight loss, which persist up to at least six months after device removal.”Related StoriesDiet and physical exercise do not reduce risk of gestational diabetesDiabetes medications mask euglycemic ketoacidosis at the time of surgerySome people treated for type 1 diabetes may have monogenic diabetes, study findsJirapinyo’s study also highlighted a clinically and statistically significant improvement in insulin resistance.Jirapinyo conducted this study according to the PRISMA statement and reviewed over 1,000 published EndoBarrier studies. Following strict inclusion and exclusion methodologies which were defined a priori, a total of 17 published studies were included in the final meta-analysis. Jirapinyo contacted authors for additional information that was needed, which contributed to making the study robust and comprehensive.”Given a rising pandemic of obesity and diabetes, DJBL may offer a highly effective treatment option for this patient population,” said Jirapinyo.”We are pleased to review the results from this comprehensive EndoBarrier meta-analysis that Dr. Jirapinyo and the clinical team at Harvard Medical School and Brigham and Women’s Hospital conducted,” said Scott Schorer, GI Dynamics president and chief executive officer. “The results confirm that EndoBarrier produces a significant reduction in HbA1c and weight, significantly reduces insulin resistance and creates a hormonal effect similar in many respects to gastric bypass.””This data clearly shows a very favorable treatment effect with significant treatment durability and a positive benefit-risk profile,” said Schorer. “This study presents the most comprehensive EndoBarrier meta-analysis we have seen and this type of data is indicative of EndoBarrier’s highly impactful clinical utility.”Source: http://gidynamics.com/2018/05/09/endobarrier-meta-analysis-published-diabetes-care-journal/